Heat Shock Protein-27 Delays Acute Rejection After Cardiac Transplantation
نویسندگان
چکیده
منابع مشابه
Heat Shock Protein-27 Delays Acute Rejection After Cardiac Transplantation: An Experimental Model
BACKGROUND Rejection is the major obstacle to survival after cardiac transplantation. We investigated whether overexpression of heat shock protein (Hsp)-27 in mouse hearts protects against acute rejection and the mechanisms of such protection. METHODS Hearts from B10.A mice overexpressing human Hsp-27 (Hsp-27tg), or Hsp-27-negative hearts from littermate controls (LCs) were transplanted into ...
متن کاملHeat Shock Protein 27 Is Associated With Freedom From Graft Vasculopathy After Human Cardiac Transplantation
Experimental studies have suggested that protective genes protect allografts from cardiac allograft vasculopathy (CAV), the major complication after cardiac transplantation. Here we have sought to confirm this hypothesis using long-term heart transplant recipients. Twenty-two patients that were 9 years or older after transplant were investigated; 11 of these were without angiographic evidence o...
متن کاملHeat shock protein 27 is associated with freedom from graft vasculopathy after human cardiac transplantation.
Experimental studies have suggested that protective genes protect allografts from cardiac allograft vasculopathy (CAV), the major complication after cardiac transplantation. Here we have sought to confirm this hypothesis using long-term heart transplant recipients. Twenty-two patients that were 9 years or older after transplant were investigated; 11 of these were without angiographic evidence o...
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BACKGROUND Heat shock protein 90 (HSP90), a molecular chaperone associated with the activation of client proteins, was recently reported to play an important role in immunologic reactions. To date, the role of HSP90 in solid organ transplantations has remained unknown. The aim of this study was to evaluate the relationship between serum HSP90α levels and acute allograft rejection after organ an...
متن کاملAcute Rejection Following Cardiac Transplantation
Nine patients have undergone cardiac transplantation at Stanford University Hospital. Three of these showed no clinical evidence of rejection and had essentially normal physical and phonocardiographic findings. There were eight distinct early rejection episodes in the other six patients. Early rejection was accompanied by decreasing QRS voltage, an early diastolic gallop, and frequently a right...
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ژورنال
عنوان ژورنال: Transplantation
سال: 2014
ISSN: 0041-1337
DOI: 10.1097/tp.0000000000000170